After completing her studies in art history Romana Schuler wrote a thesis on experimental perception in the sciences and arts with an emphasis on oscillopsia in virtual reality. In addition to her own artistic work in the fields of painting and sculpture, from 1987 she was increasingly occupied with new media in contemporary art.
She was instrumentally involved in the development of the Leopold Museum at the MuseumsQuartier Wien as a member of the Board of Artistic Directors from 1995 to 2005. In 2006/07 she was responsible for the development and conception of the new Hermann Nitsch Museum and Museumszentrum Mistelbach as sole director. Since 2010, Schuler has been lecturing on the history of experimental perception in the sciences and arts in the Digital Arts department at the University of Applied Arts in Vienna.